Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate

• Powder: Yes
• Customized: Ready to Ship
• Certification: GMP, HSE, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: jf02-1
• Intermediate: Apixaban-2
• Other Name: (Arry-470)
• Sample: Free
• Supplier: Apixaban Factory
• Heavy Metal: 10ppm
• Impurity: 0.01%
• Ros: Yes
• Annul Sales: 2000kg
• Capacity: 25000kg
• Stock: 2.00kg
• Water: 0.01%
• Market: India
• Ever Exported?: Yes
• Volume: 200kg
• Experience: 10years
• Transport Package: Air
• Specification: JP
• Trademark: jianfeng
• Origin: Shandong
• HS Code: 2939000000
• Production Capacity: 400kg

Product Description

What is apixaban intermediate CAS 536759-91-8 ?

Apixaban intermediate CAS 536759-91-8 is a pharmaceutical intermediate intended for the manufacture of the anticoagulant medication apixaban.

How to synthesize?

It is produced by a three-step synthetic process starting with 2,4,4-trimethylpentan-1-ol as the key starting material. First, it is condensed with 3-chloro-2-methylpropene to form an aldehyde, which is then reacted with 1-cyano-3-(4-ethoxycarbonyl-piperazin-1-yl)-propan-2-ol to form the desired intermediate.

The medical field use of apixaban is to reduce the risk of stroke and systemic embolism in adults with nonvalvular atrial fibrillation, to treat deep vein thrombosis and pulmonary embolism, to reduce the risk of recurrent deep vein thrombosis and pulmonary embolism, and to treat venous thromboembolism.
 

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester					503614-91-3	Apixaban intermediate
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester					27143-07-3	Apixaban intermediate
2(1H)-pyridine,3-chloro-5,6-dihydro-1-(4-nitrophenyl)					536760-29-9	Apixaban intermediate
3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one					545445-44-1	Apixaban intermediate
3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone					503615-03-0	Apixaban intermediate
Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3					536759-91-8	Apixaban intermediate
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate					503615-07-4	Apixaban intermediate
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone					1267610-26-3	Apixaban intermediate