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![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00HoClyWJhlVYv/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00HqMiFBwtrWYv/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00HoehNOAMQlRC/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00ymBitUOREJzu/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00nwMiaPNYrAgp/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/202f0j00FJvhEkyWSdug/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
What is apixaban intermediate CAS 536759-91-8 ?
Apixaban intermediate CAS 536759-91-8 is a pharmaceutical intermediate intended for the manufacture of the anticoagulant medication apixaban.
How to synthesize?
It is produced by a three-step synthetic process starting with 2,4,4-trimethylpentan-1-ol as the key starting material. First, it is condensed with 3-chloro-2-methylpropene to form an aldehyde, which is then reacted with 1-cyano-3-(4-ethoxycarbonyl-piperazin-1-yl)-propan-2-ol to form the desired intermediate.
The medical field use of apixaban is to reduce the risk of stroke and systemic embolism in adults with nonvalvular atrial fibrillation, to treat deep vein thrombosis and pulmonary embolism, to reduce the risk of recurrent deep vein thrombosis and pulmonary embolism, and to treat venous thromboembolism.
| 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester | 503614-91-3 | Apixaban intermediate | ||||
| Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester | 27143-07-3 | Apixaban intermediate | ||||
| 2(1H)-pyridine,3-chloro-5,6-dihydro-1-(4-nitrophenyl) | 536760-29-9 | Apixaban intermediate | ||||
| 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one | 545445-44-1 | Apixaban intermediate | ||||
| 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone | 503615-03-0 | Apixaban intermediate | ||||
| Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3 | 536759-91-8 | Apixaban intermediate | ||||
| ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate | 503615-07-4 | Apixaban intermediate | ||||
| 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone | 1267610-26-3 | Apixaban intermediate | ||||
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate](http://www.micstatic.com/athena/img/transparent.png)
![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/203f0j00HoClyWJhlVYv/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
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![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate pictures & photos](http://image.made-in-china.com/203f0j00nwMiaPNYrAgp/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp)
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![Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate](http://image.made-in-china.com/3f2j00HoClyWJhlVYv/Supply-CAS-536759-91-8-Apixaban-Intermediate-Ethyl-1-4-Methoxyphenyl-6-4-nitrophenyl-7-oxo-4-5-6-7-tetrahydro-1H-pyrazolo-3-4-c-pyridine-3-carboxylate.webp "Supply CAS 536759-91-8 Apixaban Intermediate Ethyl 1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4, 5, 6, 7-tetrahydro-1H-pyrazolo[3, 4-c]pyridine-3-carboxylate")
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