| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Product Name: Crisaborole
CAS No.: 906673-24-3
Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by the USFDA for the treatment of mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed , is delivered as a 2% ointment, which is applied topically. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.
It is a non steroidal phosphodiesterase 4 (PDE-4) inhibitor. It shows effective activity in vivo and in vitro. It is also used as a Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor, although its specific mechanism of action in atopic dermatitis is not known. In the US, crisaborole is indicated for topical treatment of mild to moderate atopic dermatitis in people three months of age and older. In the EU, crisaborole is indicated for treatment of mild to moderate atopic dermatitis in people two years of age and older with ≤ 40% body surface area (BSA) affected.
| Batch No. | HF171102 | Quantity | 600gs |
| Mfg. Date | Nov. 02, 2017 | Package | As required |
| Rep. Date | Nov. 05, 2017 | Exp. Date | Nov. 01, 2019 |
| Items | Standards | Results | |
| Appearance | White or off-white solid powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Solubility | Soluble in glycol | Complies | |
| Loss on Drying | ≤ 1.00% | 0.55% | |
| Residual Solvents | ≤3000ppm | ND | |
| ≤5000ppm | 4000ppm | ||
| Related Substances | Any single impurity: ≤0.30% | 0.10% | |
| Total Impurities: ≤1.00% | 0.28% | ||
| Assay (HPLC basis on drying) |
98.0%~102.0% | 99.85% | |
| Reference Standard | In-house Standard | ||
| Conclusion | The product complied to In-house standard. | ||
Storage |
Preserve in tight,light-resistant containers in a cool place | ||
| Package |
Powder: PE bag, glass bottle, or PTFE bottle for inner packing, and aluminum foil bag for outer packing. We can customize the packing according to customer's requirement. Bulk order: Fiber drum or steel drum. |
| Payment options | T/T,Paypal,L/C,Western Union,or according to your needs. |
Transportation |
UPS,TNT,EMS,Fedex,and so on.According to your location.By air or sea in large quantities. |
Q1: When will the product be shipped after payment?
---We are committed to the same day shipping.
Q2. How does your factory control quality?
All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system provided the strongest guarantee for a high-quality product.
Q3: How long will it take to receive the parcel?
--3 days for the US market; 4-6 days for the others.
Q4: What can I do if I don't have the ability to clear the custom?
--We got experience after doing export for many years, so don't worry we can handle that.
Q5: Can I get some samples?
---Yes.
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